Fisrt of all is importnat to know that Citrus Aurantium (oranges and other similar products) interacts with beta-3 receptors, not the beta-2 receptors that are the main player in human fat loss.
Citrus Aurantium share a property with grapefruit juice that doesn’t exist with ephedrine: It contains at least two substances that inhibit the cytochrome P450 enzyme system in the liver. That particular system metabolizes more than 25 percent of available drugs, and inhibiting it could lead to dangerously high concentrations of drugs in the body. CA is even more potent than grapefruit juice in that regard.
Case studies of Citrus Aurantium’s side effects are starting to appear in medical journals. Like the cases that involved ephedrine, however, they show little or no direct cause-and-effect relationship to use of CA. One case involved a 52-year-old woman who experienced unremitted tachycardia (rapid heartbeat) after taking 500 milligrams of a Citrus Aurantium supplement containing 6 percent synephrine, or 30 milligrams.4 She’d been taking thyroid medication for 10 years, however, and the doctors reporting her case suspected an interaction between thyroid hormone and Citrus Aurantium. That makes sense considering that natural cate-cholamines produced in the body can result in a similar effect when used with thyroid medication.
Another case involved a 55-year-old woman who had used a supplement containing Citrus Aurantium. She had a heart attack, which her examining physicians attributed to the Citrus Aurantium. She had no apparent cardiovascular risk factors, such as elevated blood cholesterol or lipids, high blood pressure and so on. On the other hand, she was a heavy smoker, and smoking can independently lead to a heart attack. Again, no true cause and effect to indict Citrus Aurantium.
Even if Citrus Aurantium proved to be less “dangerous” than ephedrine, it still wouldn’t compare in effectiveness to ephedrine. That’s mainly because Citrus Aurantium interacts with beta-3 receptors, not the beta-2 receptors that are the main player in human fat loss. Even worse, Citrus Aurantium has the same potential for causing an increase in blood pressure that was linked to ephedrine, and it inhibits the liver’s vital drug-detoxifying system.