Tag Archives: testosterone

Anabolic Steroids: Effects on Your Heart

3 Dec

Studies based upon valid research show prolonged high dose Anabolic Steroids (AAS)  use can have negative effects upon the heart. Eventually non-stop high dosage AAS cycles will lead to a decrease in high-density lipoprotein cholesterol (HDL). HDL protects against cardio vascular disease by shuttling cholesterol out of the blood and back to the liver.

The liver degrades cholesterol into bile and only then can it be excreted from the body. This is the only method the body has to get rid of excess cholesterol. It is not like fat which can be burned or oxidized. A possible explanation for the significant increases in low-density lip-protein (LDL) cholesterol during long AAS protocols is simply a matter of biosynthesis.

anabolic steroids

Normally the body utilizes cholesterol to synthesize sex hormones endogenously (produced inside the body). Testosterone, estrogen and others all begin as cholesterol. When AAS are introduced exogenously, this process is inhibited.

This in turn allows cholesterol to build-up to dangerous levels until discontinuance of the AAS. An interesting fact is that anything that stimulates HPTA (hypothalamuspituitary- testes-axis) function/activity also decreases bad cholesterol levels. It does so by increasing hormone (like testosterone) production endogenously. Oral AAS have the greatest negative effects upon HDL, while nandrolone have little or no negative effect. In fact there are some studies that support the belief that nandrolones have a positive effect upon HDL levels, though its is not scientifically proven yet.

Testosterone: A General Overview

7 Nov

testosterone athleteTestosterone is not a static pres­ence in the blood. Its normal con­centration varies among age groups, races, individuals; even in the same person, it not only varies from season to season, but hour to hour! If a man’s serum (blood) testosterone concentration were plotted on a graph, it would have as many ups and downs as the stock market has shown these past months. To compli­cate matters further, the effects of testosterone are not dependent solely upon the concentration of testos­terone in the blood (serum), but also on androgen receptor density, struc­ture, converting enzymes, co-factors (both activators and suppressors), genotype, nutritional status, non-genomic receptors, etc. Even when restricting the evaluation of a man’s androgen status to serum testos­terone measures, there remain a number of variables, including: sex hormone-binding globulin (SHBG); albumin; etc.testosterone structure

Few people understand the greater scope of testosterone’s roles and action in human physiolo­gy. Certainly, there has been no call by academics, professional journals, the popular media or even the public to pursue, let alone fund, investiga­tions into the role of testosterone and its benefits to society and individuals. This would contrast too sharply with the emotion-laden reactionary mes­sages about the ethical violations of doping and challenges of high-risk youths abusing anabolic steroids that are so effective in gaining media attention and political backing.

Looking at testosterone objective­ly, one must admit that the illicit (ille­gal) distribution and use of testos­terone and related anabolic steroids (collectively called AAS) is problemat­ic. Despite the fact that most users are socially responsible adult men who report surprisingly moderate use, regulations need to be in place to prevent and punish illicit trafficking of AAS. Failure to do so results in the administration of abusive levels by uninformed and unsupervised users, administration of the drugs to unsuitable candidates who may have overt or covert contraindications.

testosterone cypionate

It is important to know that this arti­cle addresses testosterone deficiency in men who entered adulthood with a normal testosterone status. Conservative professional soci­eties have published treatment guidelines, dictating when androgen replacement therapy is appropriate in their consensus opinion. Licensing boards, malpractice attorneys and professional liability insurance carri­ers rely upon these societies, trusting them to provide authoritative stan­dards of professional practice.

Symptoms and signs of Testosterone Deficiency 

Strongly Suggestive

•  Low count or absent sperm

•  Reduced sexual desire (libido) and activity

•  Decreased spontaneous erections

•  Breast discomfort, gynecomastia

•  Loss of body (axillary and pubic) hair

•  Reduced need to shave

•  Testicular atrophy

•  Loss of height, easily broken bones

•  Low bone mineral density (osteoporosis)

•  Reduction in muscle strength and mass

•  Hot flushes, sweats (similar to a woman’s hot flash)

Weakly Suggestive

•  Loss of energy, motivation, initiative

•  Lessened aggression, self-confidence

•  Depressed mood, feeling “blue”

•  Memory and concentration problems

•  Sleep disturbance, fatigue, sleepiness

•  Mild anemia (low red blood cell count)

•  Increase in body fat or BMI

•  Exercise intolerance, poor work performance

Betel Nuts and Testosterone

1 Nov

Arecoline is one of the major components of betel nuts, which have been consumed as chewing gum in Southeast Asia. In fact, some people chew these nuts because of the mild stimulant effect. But there is something even more intriguing about arecoline, an active component of betel nuts. And that is its effect on testosterone.

betel nuts

In this recent study, the effects of arecoline on testosterone  secretion were studied in male rats that were injected with human chorionic gonadotropin (hCG, 5 IU/kg) or arecoline (1 microg/kg) plus hCG. They discovered that one intravenous injection of arecoline resulted in an increase of the hCG-induced level of plasma testosterone. Also, administration of arecoline in-vitro  increased Testosterone production in Leydig cells (these are the  testosterone producing cells in the testicles). The stimula­tory effect of arecoline on testosterone release in-vitro was enhanced by hCG and forskolin. Thus, arecoline stimulates testosterone production by acting directly on the testes. Maybe we all should go buy some betel nuts and chew on them. This might be an addi­tional way to get a rise in Testosterone levels.

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